Cilia and coordination of signaling networks during heart development

Koefoed K, Veland IR, Pedersen LB, Larsen LA, Christensen ST

Organogenesis 2013 Dec;10(1)

PMID: 24345806

Abstract

Primary cilia are unique sensory organelles that coordinate a wide variety of different signaling pathways to control cellular processes during development and in tissue homeostasis. Defects in function or assembly of these antenna-like structures are therefore associated with a broad range of developmental disorders and diseases called ciliopathies. Recent studies have indicated a major role of different populations of cilia, including nodal and cardiac primary cilia, in coordinating heart development, and defects in these cilia are associated with congenital heart diseases. Here, we present an overview of the role of nodal and cardiac primary cilia in heart development.

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